Analysis of Intermediate Hosts and Susceptible Animals of SARS-CoV-2 by Computational Methods

COVID-19, a disease caused by SARS-CoV-2 that produces major symptoms of pneumonia, has been disaster worldwide. The traceability and the discovery susceptible animal species is crucial to halt viral transmission explore mechanism cross-species transmission. We selected 82 representative ACE2 sequences from 1000 with closest homology hACE2 protein. All proteins were subjected modeling. Potential natural intermediate hosts, as well SARS-CoV-2, analyzed systematically calculation binding free energy protein RBD SARS-CoV-2. Primates, some wild Felidae, civets, goats, spotted hyenas golden hamsters are may be potential whereas pangolins, birds reptiles unlikely hosts. Mice, rats guinea pig not Given their possible susceptibility, non-human primates, goats could potentially used experimental models examine infection without transgenesis. Herein, candidates for hosts suggested, provide guidance subsequent studies.